{"id":58,"date":"2021-11-10T11:33:54","date_gmt":"2021-11-10T03:33:54","guid":{"rendered":"http:\/\/lw.gdpmaa.com\/?p=58"},"modified":"2021-11-10T11:33:54","modified_gmt":"2021-11-10T03:33:54","slug":"%e6%a0%91%e7%aa%81%e7%8a%b6%e7%bb%86%e8%83%9e%e5%9c%a8%e8%82%ba%e7%99%8c%e5%85%8d%e7%96%ab%e4%bd%9c%e7%94%a8%e4%b8%ad%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/lw.gdpmaa.com\/?p=58","title":{"rendered":"\u6811\u7a81\u72b6\u7ec6\u80de\u5728\u80ba\u764c\u514d\u75ab\u4f5c\u7528\u4e2d\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"\n

\u3000\u674e\u56db\u9999\uff0c\u5468\u627f\u5fd7 \uff0c\u674e\u4e3a\u6c11<\/p>\n\n\n\n

\u3000\u3000\u6458\u8981<\/p>\n\n\n\n

\u3000\u3000    \u6811\u7a81\u72b6\u7ec6\u80de\u662f\u94fe\u63a5\u56fa\u6709\u3001\u9002\u5e94\u6027\u514d\u75ab\u7684\u6865\u6881\uff0c\u89e6\u53d1\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u6273\u673a\u3002\u4e0d\u540c\u4e9a\u578b \u7684 DC\u53d1\u6325\u7740\u4e0d\u540c\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002\u57fa\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u91cd\u7ec4\u75ab\u82d7\u548c\u514d\u75ab\u8c03\u8282\u5242\u4e1a\u5df2\u53d6\u5f97\u4e00\u5b9a\u7684\u7597\u6548\uff0c\u6709\u6f5c\u529b\u6210\u4e3a\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u65b0\u65b9\u5411\u3002\u672c\u6587\u7b80\u8981\u8ba8\u8bba\u4e86\u4eba\u4f53 DC\u7684\u6765\u6e90\u3001\u5206\u7c7b\u3001\u529f\u80fd\uff0c\u5f3a\u8c03\u4e86 DC\u5728\u80ba\u764c\u5fae\u73af\u5883\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u4ee5\u53ca\u57fa\u4e8e\u4e0d\u540c\u7c7b\u578bDC\u7684\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u7684\u6700\u65b0\u53d1\u73b0\u3002<\/p>\n\n\n\n

\u3000\u3000\u5173\u952e\u8bcd\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u80ba\u764c\uff0c\u514d\u75ab\u6cbb\u7597<\/p>\n\n\n\n

\u3000  \u6811\u7a81\u72b6\u7ec6\u80de\u6765\u6e90\u3001\u5206\u7c7b<\/p>\n\n\n\n

\u3000\u3000     \u6811 \u7a81 \u72b6 \u7ec6 \u80de (Dendritic cell\uff0cDC)\u8d77 \u6e90 \u4e8e \u9aa8 \u9ad3 \u9020 \u8840 \u5e72 \u7ec6 \u80de<\/p>\n\n\n\n

\u3000\u3000(Hematopoietic stem cells\uff0cHSC)\uff0c\u6210\u719f\u65f6\u4f38\u51fa\u8bb8\u591a\u6811\u7a81\u6837\u6216\u4f2a\u8db3\u6837\u7a81\u8d77\uff0c\u4ee5\u4e0d\u540c\u5f62\u5f0f\u5206\u5e03\u5728\u5404\u7c7b\u7ec4\u7ec7\u4e2d\uff0c\u4ee5\u6dcb\u5df4\u7ec4\u7ec7\u5c45\u591a[1]\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u5206\u7c7b\u590d\u6742\uff0c\u4e3b\u8981\u6839\u636e\u6765\u6e90\u3001\u5f62\u6001\u3001\u4f4d\u7f6e\u3001\u529f\u80fd\u3001\u8868\u9762\u6807\u5fd7\u7269\u3001\u6807\u8bb0\u57fa\u56e0\u53ca\u662f\u5426\u6210\u719f\u5206\u7c7b\u3002\u76ee\u524d\u53d1\u73b0\u6210\u719f DC\u4e3b\u8981\u6709\u4e24\u5927\u7c7b\uff1a\u6765\u6e90\u4e8e\u6dcb\u5df4\u6837\u5e72\u7ec6\u80de\u7684 DC(plasmacytoidDC\uff0cpDC)\u548c\u6765\u6e90\u4e8e\u9ad3\u6837\u5e72\u7ec6\u80deDC(myeloid DC,mDC)[2]\u3002pDC\u56e0\u9759\u606f\u72b6\u6001\u4e0b\u5f62\u6001\u4e0e\u6d46\u7ec6\u80de\u76f8\u4f3c\u800c\u5f97\u540d\uff0c\u4e3b\u8981\u5b58\u5728\u4e0e\u8840\u6db2\u53ca\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\uff0c\u901a\u8fc7\u8840\u6db2\u5faa\u73af\u8fdb\u5165\u6dcb\u5df4\u7ec4\u7ec7\uff0c\u5e76\u8868\u8fbe\u5c11\u91cf II\u578b\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f(major histocompatibility complex classII\uff0cMHC-II)\u53ca\u5927\u91cf CD303(BDCA2)\u3001\u9897\u7c92\u9176 B\uff08GranzymeB\uff09\u3001CD123\u7b49\u76f8\u5bf9\u7279\u5f02\u819c\u8868\u9762\u86cb\u767d\u3002mDC\u4e3b\u8981\u5305\u62ec\u4e86 I\u578b\u53ca II\u578b\u7ecf\u5178\uff08\u4f20\u7edf\uff09\u6811\u7a81\u72b6\u7ec6\u80de\uff08classical\/conventional DC,cDC\uff09\u3002cDC\u8868\u8fbe\u5927\u91cf I\u578b\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f(majorhistocompatibilitycomplexclassI\uff0cMHC-I)\u53ca MHC-II\u5206\u5b50\uff0c\u5206\u522b\u8bc6\u522b\u548c\u5904\u7406\u5185\u6e90\u6027\u53ca\u5916\u6e90\u6027\u6297\u539f\uff08antigen,Ag\uff09\uff0c\u9012\u5448\u5e76\u6fc0\u6d3b\u521d\u59cb T\u6dcb\u5df4\u7ec6\u80de\uff08naiveTcell\uff09\u3001B\u6dcb\u5df4\u7ec6\u80de\u3001NK\u7ec6\u80de\u7b49,\u542f\u52a8\u673a\u4f53\u5bf9\u75c5\u6bd2\u3001\u80bf\u7624\u7ec6\u80de\u3001\u7ec6\u83cc\u53ca\u771f\u83cc\u7b49\u53d1\u6325\u514d\u75ab\u6548\u5e94[2,3]\u3002cDC\u5bf9 Ag\u5177\u6709 \u201c\u4ea4\u53c9\u5448\u9012\u201d\u80fd\u529b\uff0c\u5373 cDC\u7684 MHCI\u80fd\u63d0\u5448\u5916\u6e90\u6027\u6297\u539f\uff0c\u800c MHCII\u80fd\u63d0\u5448\u5185<\/p>\n\n\n\n

\u3000\u3000\u6e90\u6027\u6297\u539f\u3002cDC\u6839\u636e\u7ec6\u80de\u8868\u9762\u5206\u5b50\u6807\u5fd7\uff0c\u4e3b\u8981\u5206\u4e3a CD141+ (BDCA3+)\u00a0cDC1 \u548c CD1c+(BDCA1+)cDC2\u4e9a\u578b[4]\u3002\u6b64\u5916\uff0c\u7531\u5355\u6838\u7ec6\u80de\u539f\u4f4d\u5206\u5316\u800c\u6765\u7684\u5355\u6838-\u6811\u7a81\u72b6\u7ec6\u80de(monocyte-derived\u00a0dendriticcell,Mo-DC\uff09\u5728\u673a\u4f53\u63a5\u53d7 Ag\u523a\u6fc0\u5f15\u53d1\u708e\u75c7\u53cd\u5e94\u65f6\uff0c\u5411\u6dcb\u5df4\u7ed3\u8fc1\u79fb\u5e76\u9012\u5448\u76f8\u5e94\u6297\u539f[5]\u3002\u80da\u80ce\u6765\u6e90\u5e76\u805a\u5c45\u4e8e\u7279\u5b9a\u7ec4\u7ec7\u7684\u6717\u683c\u6c49\u65af\u7ec6\u80de(Langerhans\u00a0cell\uff0cLC)\u662f\u4eba\u7c7b\u7279\u6b8a\u7684\u4e0d\u6210\u719f\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u4e3b\u8981\u5b58\u5728\u4e8e\u76ae\u80a4\u8868\u76ae\u3001\u53e3\u8154\u4ee5\u53ca\u6c14\u7ba1\u3001\u98df\u7ba1\u7c98\u819c\u3001\u6dcb\u5df4\u6837\u5668\u5b98\u7b49\uff0c\u8868\u8fbe CD45\u3001MHC-II\u3001CD1a\u53ca\u7279\u5f02\u6027 Langerin\u5206\u5b50\uff0c\u5bf9\u76ae\u80a4\u3001\u7c98\u819c\u7684\u5c4f\u969c\u529f\u80fd\u610f\u4e49\u975e\u51e1\uff08\u89c1\u56fe 1\uff09[6]\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u56fe 1 \u6811\u7a81\u72b6\u7ec6\u80de\u8d77\u6e90\u4e0e\u5206\u7c7b<\/strong><\/p>\n\n\n\n

\u3000\u3000    \u8fd1\u5e74\u6765\uff0c\u5bf9 DC\u65b0\u7c7b\u578b\u53ca\u529f\u80fd\u7684\u63a2\u7d22\u5c42\u51fa\u4e0d\u7a77\u3002\u57fa\u4e8e\u5065\u5eb7\u4eba\u5916\u5468\u8840\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u3001\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u7ed3\u679c\u63d0\u793a\uff0c\u4eba\u7c7b DC\u53ef\u4ee5\u5927\u81f4\u5212\u5206 6\u79cd\u4e9a\u578b\uff0c\u5176\u4e2d\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\u53ef\u5206\u4e3a 3\u4e2a\u4e9a\u578b\uff1acDC1(\u5206\u5b50\u6807\u5fd7\uff1aCD141,XCR1,CLEC9A,TBHD\uff0cCADM1), cDC2(\u5206 \u5b50 \u6807 \u5fd7 CD1C,CD1A,CD1E,CD207\uff0cCD36,CD163),cDC3(\u5206\u5b50\u6807\u5fd7CD1C,CD1A,CD1E,CD207\uff0cCD32B,CD36,CD163)\u3002\u5176\u4e2d\uff0cCD1C+DC\u7ec6\u5206\u4e3a CD32B\u9ad8\u8868\u8fbe\uff08non-inflammatory type\uff0ccDC3\uff09\u53ca CD32B\u4f4e\u8868\u8fbe\u4e9a\u578b\uff08inflammatory type\uff0ccDC2\uff09\u3002\u5176\u4e2d\uff0ccDC3\u9ad8\u8868\u8fbe\u6025\u3001\u6162\u6027\u708e\u75c7\u6807\u5fd7\u7269\u5982 CD14\u3001S100A9\u548c S100A8\u3002Mo-DC\u5206\u4e3a 2\u4e2a\u4e9a\u578b\uff1a\u7ecf\u5178\u578b CD1C\u2013CD141\u2013CD11C+Mo-DC\u4e0e\u65b0\u578bASDC(\u5206\u5b50\u6807\u5fd7\uff1aAXL,SIGLEC1,SIGLEC6,CD22\/SIGLEC2)\u3002ASDC\u65e2\u8868\u8fbe pDC\u67d0\u4e9b\u5206\u5b50\u6807\u5fd7\u7269\uff0c\u4ea6\u8868\u8fbe\u67d0\u4e9b cDC\u5206\u5b50\u6807\u5fd7\u7269\uff0c\u4fc3\u8fdb CD4+\u548c CD8+T\u7ec6\u80de\u7684\u5206\u5316\uff0c\u5176\u5177\u4f53\u529f\u80fd\u4ecd\u6709\u5f85\u63a2\u7d22[7]\u3002\u57fa\u4e8e NSCLC\u80ba\u7ec4\u7ec7\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u3001\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u7ed3\u679c\u65b0\u53d1\u73b0\u4e0e\u201c\u9759\u6b62\u578b\u201dcDC1\u3001cDC2\u540c\u6e90\u7684\u201c\u6d3b\u5316\u578b\u201dcDC3(\u5206\u5b50\u6807\u5fd7\u7269\uff1aFSCN1,CCR7,LY75,CCL22,BIRC3,BATF3\uff0cIRF8)\uff08\u89c1\u56fe 1\uff09[8]\u3002<\/p>\n\n\n\n

\u3000\u3000     pDC\u3001cDC\u7531 \u6811 \u7a81 \u72b6 \u7ec6 \u80de \u5171 \u540c \u524d \u4f53 \u7ec6 \u80de \uff08the common DC progenitor, CDP<\/em>\uff09\u5728\u9aa8\u9ad3\u4e2d\u5206\u5316\u800c\u6765\uff0c\u800c CDP<\/em>\u4e0e\u5355\u6838\u7ec6\u80de\u5747\u8d77\u6e90\u4e8e\u5355\u6838-\u6811\u7a81\u72b6\u7ec6\u80de\u7956\u7ec6\u80de\uff08Monocyte-Dendritic cell progenitor\uff0cMDP<\/em>\uff09\u3002\u8fd1\u671f\u7814\u7a76\u63ed\u793a\uff0c\u5728\u4eba\u7c7b\u4e2d\uff0c\u6839\u636e CD172a\/SIRP<\/em>\u03b1\u7684\u8868\u8fbe\u4e0e\u5426\uff0c CDP<\/em>\u5728\u9aa8\u9ad3\u4fbf\u5f00\u59cb\u5206\u5316\u4e3a CD172a+pre-cDC\u548c CD172a\u2212pre-cDC\uff0c\u8fc1\u5f99\u81f3\u5916\u5468\u8840\u53ca\u6dcb\u5df4\u7ec4\u7ec7\u5206\u522b\u7ee7\u7eed\u5206\u5316\u4e3a\u6210\u719fCD1c+cDCs\u548cCD141+cDCs[9]\u3002\u5728\u6dcb\u5df4\u7ed3\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u53ef\u5206\u4e3a\u201c\u5b9a\u5c45\u578b\u201d\u548c\u201c\u8fc1\u5f99\u578b\u201d\uff0c\u540e\u8005\u4ece\u5916\u5468\u7ec4<\/p>\n\n\n\n

\u3000\u3000\u7ec7\u9012\u5448\u6297\u539f\u5f15\u6d41\u81f3\u6dcb\u5df4\u7ed3\u89e6\u53d1\u540e\u7eed\u514d\u75ab\u6548\u5e94[10]\u3002<\/p>\n\n\n\n

\u3000\u3000\u6811\u7a81\u72b6\u7ec6\u80de\u514d\u75ab\u529f\u80fd<\/p>\n\n\n\n

\u3000\u3000 \u00a0\u00a0\u00a0\u6811\u7a81\u72b6\u7ec6\u80de\u901a\u8fc7 MHCI\u53ca MHC-II\u5206\u5b50\u8bc6\u522b\u3001\u541e\u566c\u5185\u6e90\u548c\u5916\u6e90\u6027\u6297\u539f\u5e76\u4f20\u9012\u4fe1\u53f7\uff0c\u662f\u529f\u80fd\u6700\u5f3a\u7684\u4e13\u804c\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u8054\u7ed3\u56fa\u6709\u514d\u75ab\u4e0e\u9002\u5e94\u6027\u514d\u75ab[1]\u3002\u5728\u80f8\u817a\u4e2d\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u53c2\u4e0e T\u7ec6\u80de\u7684\u9634\u6027\u3001\u9633\u6027\u9009\u62e9\u3001\u5206\u5316\u53ca\u514d\u75ab\u8010\u53d7\u3002\u5728\u5916\u5468\u975e\u6dcb\u5df4\u6837\u7ec4\u7ec7\u4e2d\uff0cDC\u7ec6\u80de\u6355\u83b7\u5185\u6e90\u6027\u6216\u5916\u6e90\u6027\u6297\u539f\uff0c\u901a\u8fc7 CCR7\u8d8b\u5316\u5f15\u6d41\u81f3\u6dcb\u5df4\u7ed3\uff0c\u9012\u5448\u6297\u539f\u81f3 T\u6dcb\u5df4\u7ec6\u80de\u3001B\u6dcb\u5df4\u7ec6\u80de\u3001NK\u7ec6\u80de\u7b49,\u5f15\u53d1\u514d\u75ab\u8010\u53d7\u6216\u8005\u514d\u75ab\u6d3b\u5316\u6548\u5e94[11]\u3002\u672a\u6210\u719f\u6811\u7a81\u72b6\u7ec6\u80de\u8fc1\u79fb\u80fd\u529b\u8f83\u5f3a\uff0c\u4ece\u9aa8\u9ad3\u8fdb\u5165\u5916\u5468\u8840\u5e76\u8fc1\u5f99\u81f3\u5916\u5468\u7ec4\u7ec7\u3002\u6210\u719f\u7ec6\u80de\u5219\u80fd\u6709\u6548\u6fc0\u6d3b\u521d\u59cb T\u7ec6\u80de\uff0ccDC1s\u4e3b\u8981\u5206\u5e03\u5728\u5916\u5468\u7ec4\u7ec7\u7c98\u819c\u53ca\u8840\u7ba1\u58c1\uff0c\u8bf1\u5bfc\u521d\u59cb T\u7ec6\u80de\u5206\u5316\u4e3a CD8+\u7ec6\u80de\u6bd2\u6027 T\u7ec6\u80de\uff08cytotoxicT-cell\uff0cCTL\uff09\uff0c\u53d1\u6325\u6548\u5e94\u3002cDC2s\u5219\u4e3b\u8981\u5206\u5e03\u5916\u5468\u7ec4\u7ec7\u56fa\u6709\u5c42\uff0c\u541e\u566c\u8870\u8001\u51cb\u4ea1\u7ec6\u80de\u4f7f\u5176\u86cb\u767d\u6c34\u89e3\uff0c\u4e3b\u8981\u6d3b\u5316 CD4+Th1\u3001Th2\u3001Th17\u7ec6\u80de\uff0c\u5206\u6ccc\u5927\u91cf\u4fc3\u708e\u56e0\u5b50[13]\u3002pDCs\u5e7f\u6cdb\u5206\u5e03\u5728\u80ba\u5b9e\u8d28\uff0c\u4e3b\u8981\u8bc6\u522b\u5185\u6e90\u6027\u6297\u539f\u5982\u75c5\u6bd2\u5e76\u9012\u5448\u81f3 CD8+T\u7ec6\u80de\uff0c\u4ea7\u751f\u5927\u91cf I\u578b\u5e72\u6270\u7d20\uff08IFN-\u03b1\uff09\uff0c\u53d1\u6325\u6297\u75c5\u6bd2\u4f5c\u7528\u53ca\u514d\u75ab\u8010\u53d7[6]\u3002Mo-DCs\u5faa\u73af\u4e8e\u8840\u6db2\u53ca\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\uff0c\u52df\u96c6\u5728\u708e\u75c7\u53ca\u80bf\u7624\u7ec4\u7ec7,\u6fc0\u6d3b CD4+T\u3001CD8+T\u7ec6\u80de\uff0c\u4fc3\u8fdb Th17\u7684\u5206\u5316\uff0c\u5206\u6ccc IL-6\u3001TNF-\u03b1\u3001IL1-\u03b2\u3001IL-23\u7b49\u708e\u75c7\u56e0\u5b50\u53d1\u6325\u6297\u708e\u4f5c\u7528\uff08\u89c1\u56fe 2\uff09[13]\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u56fe 2 \u6811\u7a81\u72b6\u7ec6\u80de\u514d\u75ab\u529f\u80fd<\/strong><\/p>\n\n\n\n

\u3000\u3000\u6811\u7a81\u72b6\u7ec6\u80de\u4e0e\u80ba\u764c\u7684\u80bf\u7624\u5fae\u73af\u5883<\/p>\n\n\n\n

\u3000\u3000    \u80bf\u7624\u5fae\u73af\u5883\u662f\u80bf\u7624\u7ec6\u80de\u751f\u957f\u53ca\u6f14\u5316\u7684\u5c40\u90e8\u73af\u5883\uff0c\u6d78\u6da6\u7740\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff0c\u5305\u62ec\u80bf\u7624\u76f8\u5173\u6811\u7a81\u72b6\u7ec6\u80de(tumor associated dendritic cell,TADC)[14]\u3002TADC\u4ec5\u5360\u80bf\u7624\u5fae\u73af\u5883\u514d\u75ab\u7ec6\u80de 2.1%\uff0c\u5728\u80bf\u7624\u7ec4\u7ec7\u53ca\u6dcb\u5df4\u7ec4\u7ec7\u4e2d\u8fc1\u5f99\u6d41\u52a8\uff0c\u8bc6\u522b\u5e76\u5904\u7406\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08tumor associated antigen,TAA\uff09\uff0c\u539f\u4f4d\u9012\u5448\u6216\u8005\u901a\u8fc7\u4f20\u5165\u6dcb\u5df4\u7ba1\u8f6c\u79fb\u5230\u5f15\u6d41\u80bf\u7624\u7684\u6dcb\u5df4\u7ed3\u4e2d\u523a\u6fc0\u521d\u59cb T\u6dcb\u5df4\u7ec6\u80de\u5206\u5316\u4e3a\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T\u6dcb\u5df4\u7ec6\u80de\uff0c\u4e0a\u8c03\u5171\u523a\u6fc0\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u5e76\u8c03\u8282\u7ec6\u80de\u3001\u5316\u5b66\u56e0\u5b50\u4ea7\u751f\u3001\u91ca\u653e\uff0c\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u8fd9\u4e9b\u6b65\u9aa4\u4e2d\u7684\u4efb\u4f55\u4e00\u4e2a\u6b65\u9aa4\u7684\u5931\u8d25\u90fd\u4f1a\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94[14,15]\u3002\u65e0\u8bba\u662f\u5c0f\u9f20\u8fd8\u662f\u4eba\u7c7b\u5b9e\u9a8c\u6570\u636e\u8868\u660e\uff0cTADC\u6db5\u76d6\u4e86\u51e0\u4e4e\u6240\u6709 DC\u4e9a\u7fa4\uff0c\u5404\u81ea\u53d1\u6325\u4e0d\u540c\u7684\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94[16]\u3002CD14+Mo-DC\u901a\u8fc7 IL-10\u3001IL-1\u03b2\u7b49\u4fc3\u708e\u56e0\u5b50\u7684\u5206\u6ccc\u53ca P<\/em>D-L1\u8868\u8fbe\u7684\u4e0a\u8c03\u6291\u5236\u80bf\u7624\u7ec6\u80de\u751f\u957f\u3002cDC\u53ef\u4ece\u80bf\u7624\u90e8\u4f4d\u8fc1\u5f99\u81f3\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff0c\u6fc0\u6d3b\u5927\u91cf\u521d\u59cb T\u6dcb\u5df4\u7ec6\u80de\u5206\u5316\u3001\u6210\u719f\uff0c\u53d1\u6325\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u76d1\u89c6\u6e05\u9664\u4f5c\u7528\u3002 \u5176\u4e2d cDC1\u8bf1\u5bfc CD8+T\u5206\u5316\u4e3a\u53ef\u8bc6\u522b\u5916\u6e90\u6027\u80bf\u7624\u884d\u751f\u6297\u539f\u7684\u7ec6\u80de\u6bd2\u6027 T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\uff0c\u5206\u6ccc\u9ad8\u6c34\u5e73IL-12\u3001IL-23\u3001IL-10\u7b49\u6297\u708e\u56e0\u5b50[17]\uff1bcDC2\u8bf1\u5bfc CD4+T\u5206\u5316 Th1\u3001Th2\u3001Th17\u7b49\u7ec6\u80de\uff0c\u4fc3\u8fdb IL-6\u3001IL-4\u3001TNF-\u03b1\u3001IL-17\u7b49\u708e\u75c7\u56e0\u5b50\u5927\u91cf\u91ca\u653e[2,10]\u3002\u5b9e\u9a8c\u6570\u636e\u8868\u660e\uff0c\u4e0e\u8fdc\u764c\u5bf9\u7167\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u80ba\u764c\u7ec4\u7ec7 cDC1\u3001 cDC2\u663e\u8457\u51cf\u5c11[18]\u3002\u6ce8\u5c04 cDC1\u75ab\u82d7\u7684\u5c0f\u9f20\u6297\u80bf\u7624 CTL\u6025\u5267\u5347\u9ad8,\u80bf\u7624\u4f53\u79ef\u663e\u8457\u7f29\u5c0f\uff0c\u6ce8\u5c04\u4e86 cDC2\u75ab\u82d7\u7684\u5c0f\u9f20\uff0c\u80bf\u7624\u4f53\u79ef\u4e5f\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7f29\u5c0f[14]\u3002<\/p>\n\n\n\n

\u3000\u3000 \u00a0\u00a0\u00a0\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u7f3a\u5931\u5bf9\u4e8e\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u53ca\u514d\u75ab\u6cbb\u7597\u5931\u6548\u4f5c\u7528\u5173\u952e\u3002\u80bf\u7624\u514d\u75ab\u9003\u9038\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\u662f\u5c06 DC\u7ef4\u6301\u5728\u672a\u6210\u719f\u6216\u514d\u75ab\u6291\u5236\u72b6\u6001\uff0c\u635f\u5bb3\u4e86\u5b83\u4eec\u4f5c\u4e3a AP<\/em>C\u7684\u529f\u80fd\uff0c\u4ece\u800c\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u65e0\u6cd5\u523a\u6fc0\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T\u7ec6\u80de\u5206\u5316[15]\u3002\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u5206\u6ccc IL-10\uff08\u6291\u5236 DC\u6210\u719f\u53ca\u5176\u5206\u6ccc IL-12\u7684\u80fd\u529b\uff09\u3001IL-6\uff08\u589e\u5f3a STAT3\u901a\u8def\u4fe1\u53f7\u8f6c\u5bfc\uff09\u7b49\u4e0b\u8c03 DC\u8868\u9762 MHC-II\u3001CCR7\u7684\u8868\u8fbe\uff0c\u5e72\u6270 DC\u7684\u6297\u539f\u5448\u9012\u80fd\u529b[19]\u3002\u80bf\u7624\u7ec4\u7ec7\u6d78\u6da6\u7684 Treg\u7ec6\u80de\u4ea6\u4f1a\u663e\u8457\u6291\u5236 cDC2\u6297\u539f\u9012\u5448\u3001\u8bf1\u5bfc CD4+T\u7ec6\u80de\u5206\u5316\u529f\u80fd[10]\u3002\u603b\u4e4b\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d cDC1\u3001cDC2\u7684\u6570\u91cf\u51cf\u5c11\u53ca\u529f\u80fd\u53d7\u6291\u5236\u548c Treg\u7ec6\u80de\u7684\u589e\u591a\u4e0e\u80ba\u764c\u60a3\u8005\u9884\u540e\u4e0d\u826f\u663e\u8457\u76f8\u5173\uff08\u89c1\u56fe 3\uff09[10]\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u56fe 3 \u80bf\u7624\u5fae\u73af\u5883\u5bf9\u6811\u7a81\u72b6\u7ec6\u80de\u529f\u80fd\u5f71\u54cd<\/strong><\/p>\n\n\n\n

\u3000\u3000    \u56e0\u6b64\uff0c\u901a\u8fc7 DC\u75ab\u82d7\u6ce8\u5c04\u7684\u65b9\u5f0f\u4ee5\u671f\u6062\u590d\u3001\u589e\u5f3a DC\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u514d\u75ab\u4f5c\u7528\u662f\u76ee\u524d\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u7684\u70ed\u70b9\u3002\u591a\u9879\u52a8\u7269\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u63ed\u793a\uff0c\u7eaf\u5316\u7684 TA-cDC1\u75ab\u82d7\u663e\u8457\u589e\u52a0\u6548\u5e94 T\u7ec6\u80de\u52df\u96c6\uff0c\u5e76\u4e0e\u5316\u7597\u53caP<\/em>D-1\/P<\/em>D-L1\u3001CD137\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u6cbb\u7597\u7b49\u5177\u6709\u534f\u540c\u4f5c\u7528[20,21]\u3002\u5728\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u5df2\u8bc1\u5b9e cDC2s\u75ab\u82d7\u5b89\u5168\u6709\u6548[22,23]\u3002<\/p>\n\n\n\n

\u3000\u3000\u57fa\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u5229\u7528 DC\u514d\u75ab\u539f\u6027\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u8bf1\u5bfc\u4fdd\u62a4\u6027\u53cd\u5e94\u7684\u6982\u5ff5\u5df2\u63d0\u51fa\u591a\u5e74\uff0c\u57fa\u4e8e DC\u7ec6\u80de\u7684\u4e2a\u4f53\u514d\u75ab\u7597\u6cd5\u5728\u591a\u79cd\u80bf\u7624\u4ea6\u6709\u5927\u91cf\u63a2\u7d22\u53ca\u5c1d\u8bd5[24]\u3002<\/p>\n\n\n\n

\u30001.Mo-DC<\/p>\n\n\n\n

\u3000\u3000    \u57fa\u4e8e\u53ef\u7528\u6027\u548c\u4f53\u5916\u6269\u589e\u7b49\u6280\u672f\u65b9\u9762\uff0cMo-DC\u6700\u5e38\u7528\u4e8e\u75ab\u82d7\u63a5\u79cd\u76ee\u7684\u3002\u76f8\u8f83\u5176\u4ed6 DC\u4e9a\u578b\uff0cMo-DC\u66f4\u5bb9\u6613\u5728\u4f53\u5916\u901a\u8fc7\u7c92\u7cfb-\u5de8\u566c\u96c6\u843d\u523a\u6fc0\u56e0\u5b50(granulocyte macrophage colony-stimulating factor\uff0cGM-CSF)\u53ca IL-4\u523a\u6fc0\u5916\u5468\u8840\u4e2d CD14+\u5355\u6838\u7ec6\u80de\u6216\u8005 CD34+HSP<\/em>Cs\u5206\u5316\u800c\u5927\u91cf\u4ea7\u751f[26,27]\u3002\u7136\u800c\uff0c\u65e2\u5f80\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0cMo-DC\u75ab\u82d7\u6548\u679c\u4e0e\u9884\u671f\u4ecd\u6709\u5dee\u8ddd\uff0c\u539f\u56e0\u53ef\u80fd\u662f\u4f53\u5916\u7ecf GM-CSF\u53ca IL-4\u8bf1\u5bfc\u5206\u5316\u3001\u57f9\u517b\u7684 Mo-DC\u4e0e\u5929\u7136\u7684 Mo-DC\u5728\u57fa\u56e0\u8868\u8fbe\u53ca\u514d\u75ab\u529f\u80fd\u6709\u6240\u5dee\u5f02[30]\uff0c\u6b64\u5916\uff0c\u4f53\u5916\u57f9\u517b\u7684 Mo-DC\u8fc1\u5f99\u80fd\u529b\u53ca\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff08IL12\u3001 IFN-\u03b3\uff09\u4ea6\u53d7\u9650[14]\u3002\u56e0\u6b64\uff0c\u5728\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u65b9\u9762\uff0cMo-DC\u75ab\u82d7\u662f\u5426\u4f18\u4e8e\u5176\u4ed6DC\u4e9a\u578b\uff0c\u5c1a\u4e0d\u6e05\u695a\uff0c\u5e76\u4e14\u53ef\u80fd\u53d6\u51b3\u4e8e\u80bf\u7624\u7c7b\u578b\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u7ec4\u6210\u3002<\/p>\n\n\n\n

\u3000\u30002. cDC<\/p>\n\n\n\n

\u3000\u3000    cDC1\u5728\u80bf\u7624\u514d\u75ab\u76d1\u89c6\u4e2d\u610f\u4e49\u91cd\u5927\uff0ccDC1\u8bf1\u5bfc\u5206\u5316\u7684\u80bf\u7624\u7279\u5f02\u6027CD8+CTL\u3001NK\u548c NKT\u5bf9\u80bf\u7624\u7ec6\u80de\u5177\u6709\u76f4\u63a5\u6216\u95f4\u63a5\u6740\u4f24\u4f5c\u7528\uff0c\u662f\u751f\u4ea7\u75ab\u82d7\u7edd\u4f73\u7684\u9009\u62e9[14,28]\u3002\u8fd1\u5e74\u6765\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u5206\u6790\u7ed3\u679c\u8868\u660e cDC1\u4e0e\u6291\u5236\u6027\u914d\u4f53\u5982 P<\/em>D-L1\u8868\u8fbe\u589e\u9ad8\u3001NSCLC\u4e0d\u826f\u9884\u540e\u7d27\u5bc6\u76f8\u5173[28,29]\u3002\u76ee\u524d\u5bf9 cDC1\u5728\u80bf\u7624\u514d\u75ab\u76d1\u89c6\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u514d\u75ab\u7597\u6cd5\u4ecd\u5728\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e2d[27]\u3002<\/p>\n\n\n\n

\u3000\u3000    cDC2\u867d\u4e0d\u5982 cDC1\u77a9\u76ee\uff0c\u5176\u8bf1\u5bfc\u5206\u5316\u7684 Th17\u7684\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u6108\u53d1\u53d7\u5230\u91cd\u89c6[32]\u3002\u4ece\u4eba\u5916\u5468\u8840\u5206\u79bb\u57f9\u517b\u7684 cDC2\u75ab\u82d7\u5df2\u5728\u4e34\u5e8a\u4e0a\u8bc1\u5b9e\u6539\u5584\u90e8\u5206\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\u9884\u540e\uff0c\u5728\u80ba\u764c\u4e2d\u7684\u5e94\u7528\u6709\u5f85\u66f4\u591a\u7684\u7814\u7a76[23]\u3002<\/p>\n\n\n\n

\u3000\u30003. pDC<\/p>\n\n\n\n

\u3000\u3000    \u9996\u4e2apDC\u75ab\u82d7\u4e34\u5e8a\u8bd5\u9a8c\u7eb3\u516515\u540d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u5916\u5468\u8840\u5206\u79bbpDC\u4f53\u5916\u57f9\u517b\u3001\u523a\u6fc0\u3001\u5206\u5316\u540e\u56de\u8f93\u4f53\u5185\u5e76\u4ea7\u751fIFN-\u03b1\uff0c\u89c2\u5bdf\u5230CD4+\u6dcb\u5df4\u7ec6\u80de\u548cCD8+T\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316[22]\u3002\u5c3d\u7ba1\u76ee\u524d\u76f8\u5173\u7814\u7a76\u4e0d\u591a\uff0cpDC\u5728\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u9010\u6e10\u5f15\u8d77\u91cd\u89c6[30]\uff0cpDC\u75ab\u82d7\u5177\u6709\u6f5c\u5728\u7684\u6297\u80bf\u7624\u80fd\u529b[31]\u3002<\/p>\n\n\n\n

\u3000\u30004. \u6df7\u5408 DC\u75ab\u82d7<\/p>\n\n\n\n

\u3000\u3000   \u6bcf\u7c7b DC\u4e9a\u7fa4\u901a\u8fc7\u4e0d\u540c\u673a\u5236\u53d1\u6325\u7740\u514d\u75ab\u6548\u5e94\uff0c \u5355\u79cd\u7c7b\u7684 DC\u75ab\u82d7\u5728\u67d0\u4e9b\u7279\u5b9a\u80bf\u7624\u53ca\u4eba\u7fa4\u4e2d\u8bc1\u5b9e\u6709\u6548\u3002\u968f\u7740\u4f53\u5916 DC\u7ec6\u80de\u7684\u8bf1\u5bfc\u3001\u5206\u5316\u3001\u57f9\u517b\u66f4\u7cbe\u786e\u5316\uff0c\u6df7\u5408\u578b\u7684 DC\u75ab\u82d7\u6548\u679c\u503c\u5f97\u671f\u5f85[32]\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u7eb3\u7c73\u6280\u672f\uff0c\u8f7d\u6709\u80bf\u7624\u6297\u539f\u7684\u5c0f\u5206\u5b50\u514d\u75ab\u8c03\u8282\u5242\uff0c\u901a\u8fc7\u5728\u4f53\u5185\u523a\u6fc0\u5185\u6e90\u6027 DC\u4ea7\u751f\u4ea6\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u70ed\u70b9[24]\u3002<\/p>\n\n\n\n

\u3000\u3000<\/strong>\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n\n\n\n

\u3000\u3000     \u6811\u7a81\u72b6\u7ec6\u80de(DCs)\u4e13\u804c\u9012\u5448TAA\u81f3\u521d\u59cbT\u6dcb\u5df4\u7ec6\u80de\u5e76\u8bf1\u5bfc\u5176\u5206\u5316\u4e3a\u6548\u5e94T\u7ec6\u80de\uff0c\u4e3a\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u5951\u673a\u3002\u8fd1\u5e74\u6765\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7ed3\u5408\u6d41\u5f0f\u7ec6\u80de\u672f\u5728\u6811\u7a81\u7ec6\u80de\u5206\u7fa4\u53ca\u529f\u80fd\u9274\u5b9a\uff0c\u4ee5\u53ca\u9610\u660e\u5b83\u4eec\u5728TME\u4e2d\u4f5c\u7528\u673a\u5236\u4e2d\u6709\u8bf8\u591a\u53d1\u73b0\u4e0e\u63a2\u7d22\u3002\u6709\u7814\u7a76\u66fe\u901a\u8fc7\u6536\u96c6\u3001\u57f9\u517b\u80ba\u764c\u80f8\u8154\u79ef\u6db2\u4e2dDC\u524d\u4f53\u7ec6\u80de,\u52a0\u5165GM-CSF\u3001IL-4\u53caTNF-\u03b1\u8bf1\u5bfc\u5206\u5316\u4e3a\u6210\u719f\u7684DC\u3002\u7ed3\u679c\u663e\u793a,\u57f9\u517b\u6210\u719f\u7684DC\u5bf9\u81ea\u4f53\u764c\u7ec6\u80de\u6709\u8f83\u5f3a\u7684\u6740\u4f24\u4f5c\u7528[33]\u3002\u867d\u7136\u57fa\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u4f46\u6709\u671b\u6210\u4e3a\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u3000\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n

\u3000\u30001  MildnerA, JungS.Development and function of dendritic cell subsets[J]. Immunity,2014,40(5):642-56.<\/p>\n\n\n\n

\u3000\u30002  CollinM, BigleyV.Human dendritic cell subsets:an update[J].Immunology,<\/p>\n\n\n\n

\u3000\u30002018,154(1):3-20.<\/p>\n\n\n\n

\u3000\u30003  ChistiakovDA, SobeninIA, OrekhovAN,etal.Myeloid dendritic cells \uff1aDevelopment, functions, and role in atherosclerotic inflammation[J].Immunobiology,2015,220(6):833-44.<\/p>\n\n\n\n

\u3000\u30004  GuilliamsM,GinhouxF,JakubzickC,etal.Dendritic cells,monocytes and macrophages: a unified nomenclature based on ontogeny[J].NatRevImmunol,<\/p>\n\n\n\n

\u3000\u30002014,14(8):571-8.<\/p>\n\n\n\n

\u3000\u30005  DominguezPM,ArdavinC.Differentiation and function of mouse monocyte-derived dendritic cells insteady state and inflammation[J].Immunol Rev,2010,234(1):90-104.<\/p>\n\n\n\n

\u3000\u30006   CollinM,McgovernN,HaniffaM.Human dendritic cell subsets[J]. Immunology,2013,140(1):22-30.<\/p>\n\n\n\n

\u3000\u30007  VillaniAC,SatijaR,ReynoldsG,etal.Single-cell RNA-seq reveals new types Of human blood dendriti ccells,monocytes,and progenitors[J].Science,2017,356(6335):<\/p>\n\n\n\n

\u3000\u30008  ZilionisR,EngblomC,PfirschkeC,etal.Single-Cell Transcriptomics of Humanand Mouse Lung Cancers Reveals Conserved Myeloid Populations Across Individuals and Species[J].Immunity,2019,50(5):1317-34.e10.<\/p>\n\n\n\n

\u3000\u30009  BretonG,ZhengS,ValierisR,etal.Human dendritic cells(DCs) are derived From distinct circulating precursors that are precommitted to become CD1c+or CD141+DCs[J].J ExpMed, 2016,213(13):2861-70.<\/p>\n\n\n\n

\u3000\u300010  BinnewiesM,MujalAM,PollackJL,etal.UnleashingType-2Dendritic Cells To Drive Protective Antitumor CD4(+)T Cell Immunity[J].Cell,2019,177(3):556-71e16.<\/p>\n\n\n\n

\u3000\u300011  EisenbarthSC.Dendritic cell subsets in Tcell programming:location Dictates function[J]. Nature Reviews Immunology,2019,19(2):89-103.<\/p>\n\n\n\n

\u3000\u300012  MeradM,SatheP,HelftJ,etal.The dendritic cell lineage:ontogeny and Function of dendritic cells and their subsets in the steady state and the inflamed setting[J].Annu Rev Immunol,2013,31(563-604.<\/p>\n\n\n\n

\u3000\u300013  ShindeP,FernandesS,MelinkeriS,etal.Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy [J].Scientific Reports,2018,8<\/p>\n\n\n\n

14  LaouiD,KeirsseJ,MoriasY,etal.The tumour microenvironment harbours Ontogenically distinct dendritic cell populations with opposing effects on tumour immunity[J].Nat Commun,2016,7(13720.<\/p>\n\n\n\n

\u3000\u300015  Bandola-SimonJ,RochePA.Dysfunction of antigen processing and Presentation by dendritic cells in cancer[J].MolImmunol,2019,113(31-7.<\/p>\n\n\n\n

\u3000\u300016  KissM,VanGassenS,MovahediK,etal.Myeloid cell heterogeneity in cancer:not a single cell alike[J].CellImmunol,2018,330(188-201.<\/p>\n\n\n\n

\u3000\u300017  DiBlasioS,WortelIM,VanBladelDA,etal.HumanCD1c(+)DCs are critical Cellular mediators of immune responses induced by immunogeni ccell death[J]. Oncoimmunology,2016,5(8):e1192739.<\/p>\n\n\n\n

\u3000\u300018  GabrilovichD.Mechanisms and functional significance of tumour-induced<\/p>\n\n\n\n

\u3000\u3000dendritic-cell defects[J].Nat Rev Immunol,2004,4(12):941-52.<\/p>\n\n\n\n

\u3000\u300019  LuY,XuW,GuY,etal.Non-small Cell Lung Cancer Cells Modulate the<\/p>\n\n\n\n

\u3000\u3000DevelopmentofHumanCD1c Conventional Dendritic Cell Subsets MediatedbyCD103andCD205[J].<\/p>\n\n\n\n

\u3000\u300020  SalmonH,IdoyagaJ,RahmanA,etal.Expansionand Activation of CD103(+)<\/p>\n\n\n\n

\u3000\u3000Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to<\/p>\n\n\n\n

\u3000\u3000TherapeuticPD-L1andBRAFInhibition[J].Immunity,2016,44(4):924-38.<\/p>\n\n\n\n

\u3000\u300021  Sanchez-PauleteAR,CuetoFJ,Martinez-LopezM,etal.Cancer Immunotherapy with Immuno modulatory Anti-CD137andAnti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells[J].Cancer Discov,2016,6(1):71-9.<\/p>\n\n\n\n

\u3000\u300022  TelJ,AarntzenEH,BabaT,etal.Natural human plasmacytoid dendritic Cells induce antigen-specificT-cellresponsesinmelanomapatients[J].Cancer Res,2013,73(3):1063-75.<\/p>\n\n\n\n

\u3000\u300023  SchreibeltG,BolKF,WestdorpH,etal.Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells[J].Clin Cancer Res,2016,22(9):2155-66.<\/p>\n\n\n\n

\u3000\u300024  WculekSK,CuetoFJ,MujalAM,etal.Dendritic cells in cancer immunology And immunotherapy[J].Nat Rev Immunol,2020,20(1):7-24.<\/p>\n\n\n\n

\u3000\u300025  PerezCR,DePalmaM.Engineering dendritic cell vaccines to improve Cancer immunotherapy[J].Nat Commun,2019,10(1):5408.<\/p>\n\n\n\n

26  SaxenaM,BalanS,RoudkoV,etal.Towards superior dendritic-cell vaccines For cancer therapy[J].Nat BiomedEng,2018,2(6):341-6.<\/p>\n\n\n\n

\u3000\u300027  HuberA,DammeijerF,AertsJ,etal.Current State of Dendritic Cell-Based Immunotherapy : Opportunities for invitro Antigen Loading of Different DC Subsets?[J].Front Immunol,2018,9(2804.<\/p>\n\n\n\n

\u3000\u300028  CancelJC,CrozatK,DalodM,etal.Are Conventional Type1 Dendritic Cells Critical for Protective Antitumor Immunity and How?[J].Frontiers in Immunology,2019,10<\/p>\n\n\n\n

\u3000\u300029  ZilionisR,EngblomC,PfirschkeC,etal.Single-Cell Transcript omics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations Across Individuals and Species[J]. Immunity,2019,50(5):1317<\/p>\n\n\n\n

\u3000\u300030  LuY,XuW,GuY,etal.Non-small Cell Lung Cancer Cells Modulate the Development of HumanCD1c(+)Conventional Dendritic Cell Subsets Mediated By CD103 and CD205[J].FrontImmunol,2019,10(2829.<\/p>\n\n\n\n

\u3000\u300031 \u9648\u6842\u601d,\u738b\u60a6,\u5434\u5a49\u6587,etal.\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u4e0e\u80bf\u7624\u514d\u75ab [J].\u5e7f\u4e1c\u836f\u79d1\u5927\u5b66\u5b66\u62a5,2018,34(04):533-7.<\/p>\n\n\n\n

\u3000\u300032  ReinigerL,TeglasiV,PipekO,etal.Tumor necrosis correlates with PD-L1And PD-1 expression in lung adenocarcinoma[J].ActaOncol,2019,58(8):1087-94.<\/p>\n\n\n\n

\u3000\u300033 \u674e\u5f69\u971e,\u82cf\u79c0\u5170,\u674e\u56fd\u534e,etal.\u80ba\u764c\u80f8\u8154\u79ef\u6db2\u6811\u7a81\u72b6\u7ec6\u80de\u57f9\u517b\u4e0e\u9274\u522b\u53ca\u5176\u6297\u80bf\u7624\u4f5c\u7528\u7684\u89c2\u5bdf [J].\u4e2d\u534e\u80bf\u7624\u9632\u6cbb\u6742\u5fd7,2012,19(21):1640-2+69.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3000\u674e\u56db\u9999\uff0c\u5468\u627f\u5fd7 \uff0c\u674e\u4e3a\u6c11 \u3000\u3000\u6458\u8981 \u3000\u3000    \u6811\u7a81\u72b6\u7ec6\u80de…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/posts\/58"}],"collection":[{"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=58"}],"version-history":[{"count":1,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/posts\/58\/revisions"}],"predecessor-version":[{"id":62,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=\/wp\/v2\/posts\/58\/revisions\/62"}],"wp:attachment":[{"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=58"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=58"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/lw.gdpmaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=58"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}